User:Nikolay Borisov
From BioNetWiki
Nikolay Borisov (e-mail: nikolay.borisov@jefferson.edu) is Post-doctoral researcher at the Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA [1] and Principal research scientist at State Research Center - Institute of Biophysics, Moscow, Russia [2]. Dr. Borisov is the author of > 40 peer reviewed scientific articles. He holds a Ph.D. from Moscow Engineering Physics Institute, Russia [3] (1999).
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Research Interests
Computational physics; Radiation safety of man and environment; Monte Carlo methods for radiation transport kinetics; Spectrometry of incorporated radionuclides; Computational Systems Biology; Cancer research
The field of cancer research embraces multiple interdisciplinary investigations where advanced methods of computational mathematics need to be applied. Besides physical aspects of radiology and dosimetry that require accurate representation of ionizing radiation transport within accurately described human body, the biochemical machinery of carcinogenesis is of extreme interest. Systems biology seeks for both precise and effective methods for quantitative analysis of cell signaling that form mitogenic response of the cell which is particularly important for cancer prevention and treatment.
Professional Experience
09/2003-present Post-doctoral researcher, Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA.
02/2003-present Principal research scientist, State Research Center - Institute of Biophysics, Moscow, Russia.
02/2000-01/2003 Post-doctoral researcher, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France.
06/1999-01/2000 Assistant professor, Moscow Engineering Physics Institute (State University), Moscow, Russia.
Selected Publications
Kiyatkin A, Aksamitiene E, Markevich NI, Borisov NM, Hoek JB, Kholodenko BN (2006). Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops. J Biol Chem, 281, 19925-19938.
Borisov NM, Markevich NI, Hoek JB, Kholodenko BN (2006). Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains. BioSystems, 83, 152-66.
Yatsenko VN, Kochetkov OA, Borisov NM, Gusev I, Vlasov P, Kalistratova A, Nisimov P, Levochkin F, Borovkov M, Stolyarov V, Tsedish S, Tyurin I, Franck D, de Carlan L (2005). Check of the Application of the Monte Carlo Method for Spectrometry of Human Body Radiation in an Experiment on Large Animals. Atomic Energy, 99, 503-510.
Borisov NM, Markevich NI, Hoek JB & Kholodenko BN (2005) Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity. Biophys J, 89, 951-966.
Borisov NM, Panin MP. Generalized particle concept for adjoint Monte Carlo calculations of coupled gamma ray-electron-positron transport (2005). Nuclear Sci Engng, 150, 284-298.
Borisov NM, Kochetkov OA, Yatsenko VN, Franck D, de Carlan L, Tsedish STs. (2004). Modern internal-irradiation dosimetry. Atomic Energy, 97, 713–719.
De Carlan L, Aubineau-Laniece I, Lemosquet A, Borissov N, Jourdain JR, Jeanbourquin D, Le Guen B, Franck D (2003). Application of new imaging and calculation techniques to activity and dose assessment in the case of a Ru-106 contaminated wound. Radiat Prot Dosimetry, 105, 219-223.
Franck D, Borissov N, de Carlan L, Pierrat N, Genicot JL, Etherington G (2003). Application of Monte Carlo calculations to calibration of anthropomorphic phantoms used for activity assessment of actinides in lungs. Radiat Prot Dosimetry, 105, 403-408.
Borisov N, Franck D, Laval L, de Carlan L (2002). A new Graphical User Interface for fast construction of computation phantoms and MCNP calculations: application to calibration of in vivo measurement systems. Health Phys, 83, 272-280.
Miscellaneous Wiki Topics
Nikolay Borisov is one of the contributors of Russian Wikipedia [4]. His major interests in Wikipedia development concentrate around the popularization of objective scientific knowledge, defending it against numerous pseudo-scientific, however heavily loaded with ideology, concepts such as creationism/ID, telegony/"wave genomics", Holocaust denial, "new chronology"/"Fomenkoism" etc.
